Perspectives on the PREDICT Trial
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Milton Packer, MD
on the challenges
with current approaches
to HF assessment
Clyde Yancy, MD
on the need for objective
markers of HF
decompensation
William Abraham, MD
on the value of the
PREDICT trial
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PRospective Evaluation of Cardiac Decompensation in Patients
with Heart Failure by Impedance Cardiography Test:
The PREDICT Multicenter Trial
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This study sought to assess the utility of impedance
cardiography (ICG) in predicting clinical deterioration
in ambulatory patients with heart failure (HF).
Multivariate analysis identified 6 clinical and ICG variables that independently predicted an event
(death, HF hospitalization or ED visit within 14 days
of assessment). When the independent ICG predictor variables were combined into a composite score, they were the powerful predictor of an event in the study.
High risk visits with a stroke index <35 ml/m2 and thoracic fluid content >35 /kOhm had 7 times the risk for an event than low risk visits with a stroke index
>35 ml/m2 and a thoracic fluid content <35 /kOhm.
These results suggest that when performed at regular intervals in stable patients with HF with a recent episode of clinical decompensation, ICG can identify patients at increased near-term risk of recurrent decompensation.
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Complimentary Download: PREDICT Original Paper
Note: J Am Coll Cardiol requires a quick plug-in download to view this PDF file
Packer M, Abraham WT, Mehra MR, et al. Utility of Impedance Cardiography for the Identification of Short-Term Risk of Clinical Decompensation in Stable Patients With Chronic Heart Failure. J Am Coll Cardiol. 2006;47(11):2245-52. 
 Medical Education Satellite Program: Heart Failure
Hemodynamic Factors in Heart Failure: Diagnostic, Prognostic, and Therapeutic Role of Impedance Cardiography
Presenters: Barry H. Greenberg, MD, J. Thomas Heywood, MD and Milton Packer, MD
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